Diabinese 250 mg 100 Tabs
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Type 2 diabetes mellitus is a serious lifestyle disorder in which the pancreas are unable to produce enough insulin. This in turn is unable to maintain optimum levels of blood glucose. Diabinese is commonly advised to manage diabetes.

Gradually the signs and symptoms develop and they are listed as below:

  • Blurred vision
  • Increased hunger/thirst/fatigue
  • Weight loss or weight gain
  • Frequent infections/urination
  • Slow wound healing
  • Darkening of skin areas around neck and in the armpits

There are certain risks factors for acquiring T2DM and they can be both under your control or uncontrolled. They are listed as below:

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  • If you are among the elderly population
  • Pre-disposed genetic condition, race/ethnicity
  • Pre-diabetic condition
  • High levels of high triglycerides (bad fat), low HDL (good fat) and HBP
  • Obesity and unhealthy lifestyle choices such as eating sugary foods and drink, lack of physical activity etc.
  • If developed gestational diabetes when you were pregnant, polycystic ovarian syndrome

If left untreated, then the chronic condition of diabetes can lead to serious malfunctioning of vital organs. They are listed as below:

  • Cardiovascular complications
  • Kidney/eye/nerve/ear damage
  • Alzheimer’s disease
  • Sexual dysfunction
  • Infectious sores
  • Sleep apnoea

Action Mechanism of chlorpropamide:

Chlorpropamide is a sulfonylurea agent of second-generation class. It is an oral antihyperglycemic agent which actively binds to plasma protein upon consumption.

The site of action mechanism of the drug is at pancreatic cell surface. It binds to ATP-sensitive potassium channels causing depolarization of the membrane and reducing potassium conductance.

This mechanism leads to calcium ion influx through voltage-sensitive calcium channels by stimulating β cells of the pancreas to release insulin. It raises the secretion or exocytosis of insulin.

This enhances the way your body metabolizes glucose. Enabling glucose to enter your cells and lowering the amount of sugar in your bloodstream.

This medication must be taken only with the physician’s recommendation.

Benefits of Diabinese:

There are several studies conducted by doctors to understand the clinical importance of chlorpropamide. And there are various conclusions drawn after the studies to confirm the beneficial use of the drug.

When combined with healthy lifestyle choices such as a timely exercise routine and a balanced diet, Diabinese is able to maintain blood glucose levels effectively in patients with type 2 diabetes.

It should only be consumed with the doctor’s prescription.

Dosage and storage of Diabinese:


Diabinese is an oral drug and there are various formulations and dosages available. At BuyUrMed, following formulations and strengths are available:

  • Tablets - 250 mg

Take it exactly as per your doctor instruction.


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  • Store it below 30°C (86°F).
  • Check the expiration of the drug.
  • Store it away from children and pet’s reach.
  • Store it in a tight, light resistant container.
  • Dispose the drug as instructed on the drug leaflet.
  • Avoiding flushing down the drug in toilet or in household waste.

Precautions while taking Diabinese:

  • Before taking Diabinese, tell your doctor if you are allergic to chlorpropamide or any inactive component of the medication.
  • Tell your doctor if you had heart disease, kidney disease, adrenal or pituitary gland disorder, diabetic ketoacidosis, active liver disease, thyroid problems, poor diet, G6PD deficiency, irregular eating patterns and electrolyte imbalance (low sodium blood level).
  • Avoid alcohol consumption because it can cause low blood sugar. It can also interact with chlorpropamide and cause a serious reaction.
  • Please avoid getting stressed as that spikes the blood sugar level.
  • Use sunscreen and wear protective clothing in the sun, as this medication may cause you to become sensitive to the sun.
  • Monitor the elderly patients with more caution as they are more sensitive to the side effects of this drug, especially low blood sugar and fluid/electrolyte imbalance.
  • Before undergoing any surgeries, inform your doctor or dentist about your medication.
  • It is not advised to use Diabinese along with drug like salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents, miconazole, other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, calcium channel blocking drugs, phenytoin, nicotinic acid, sympathomimetics, and isoniazid.
  • This medication is not recommended in pregnant and breast-feeding women. You should discuss the benefits and risk of it with your doctor if it is absolute necessary.

Side Effects of Diabinese:

There are various side-effects of this medication. Common side effects are listed below:

  • nausea
  • vomiting
  • weight gain
  • diarrhoea
  • anorexia
  • hypoglycaemia
  • hyperglycaemia
  • indigestion
  • passing of gas

In addition to the above, there are some rare and adverse side-effects that have also been reported by people. These are listed as below:

  • irregular heartbeat
  • hepatic porphyria
  • depression
  • dizziness
  • seizures
  • headache
  • lethargy
  • light headedness
  • serious allergic reaction like rash, itching, swelling especially of the face/tongue/throat

This list does not include all the side effects and if you experience any aggravated reaction, you must immediately contact your doctor immediately or rush to the nearest emergency unit. 

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